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A. S. Ryzhkova, A. A. Makeeva, Z. A. Zagvozdin, A. V. Shabatin, O. I. Vernaya, A. M. Semenov, T. I. Shabatina
Green synthesis of silver nanoparticles
and cryochemical fabrication of Ag/dioxidine/gelatin composite systems
Abstract
Abstract.
In recent decades, a green
approach to producing metal and metal oxide nanoparticles with pronounced
antibacterial activity, such as silver nanoparticles, has been actively developed.
This method is characterized by its environmental friendliness, low cost, and
biocompatibility of the resulting materials. In this study, silver
nanoparticles were synthesized using an aqueous extract of Quercus robur
bark. The composition and size of the particles were determined using UV
spectroscopy, transmission electron microscopy (TEM), and dynamic light
scattering. The resulting nanoparticles, as well as previously synthesized
silver nanoparticles using aqueous extracts of Matricaria chamomilla and
Calendula officinalis flowers, were incorporated into gelatin-based
biopolymer matrices using cryochemical modification, along with the
antibacterial agent dioxidine. The composition and morphology of the hybrid
systems were determined using FTIR spectroscopy and scanning electron
microscopy (SEM), the kinetics of drug release were established, and the
antibacterial activity against Escherichia coli and Staphylococcus
aureus was determined. Synergistic effects were observed, enhancing
antibacterial activity when combining plant extracts with silver nanoparticles,
as well as when combining extracts, silver nanoparticles, and dioxidine.
However, the simultaneous presence of plant extracts and dioxidine without
silver nanoparticles resulted in antibacterial activity decreasing.
Key words: green synthesis, silver nanoparticles, Quercus
robur, Matricaria chamomilla, Calendula officinalis, dioxidine, gelatin,
cryochemical modification, synergistic effect, antibacterial activity
Copyright (C) Chemistry Dept., Moscow State University, 2002
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