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A. S. Shumilkin, A. S. Kravchenko, O. I. Vernaya, A. V. Shabatin, Yu. N. Morozov, T. I. Shabatina
Cryomodification
of dioxidine by cryogenic spray-drying: effect of process parameters on
physicochemical properties
Abstract
Abstract.
Cryochemical technologies provide a powerful tool for the targeted modification
of the morphology and crystal structure of pharmaceutical powders. These
changes significantly influence key physicochemical and biopharmaceutical
properties of drugs, including dissolution rate, specific surface area,
saturation solubility, and pharmacological activity. In the present study,
spray cryogenic drying was employed to modify the structure and morphology of
the antibacterial medicine dioxidine. It was demonstrated that cryomodification
substantially alters the physicochemical characteristics of dioxidine, such as
its dissolution rate, specific surface area, particle size distribution, and
antibacterial activity. The effects of the main process parameters –
concentration and temperature of the sprayed precursor solution – on the
structural and morphological properties of the resulting cryomodified dioxidine
powder were systematically investigated. The phase composition and crystal
structure of both the initial pharmacopoeial dioxidine and the cryomodified
samples were characterized by X-ray diffraction (XRD), UV- and FTIR-
spectroscopy. The morphology and particle size of the powders were examined by
scanning electron microscopy (SEM), while the specific surface area was
determined by low-temperature argon adsorption.
Key words: dioxidine, cryogenic spray-drying, cryomodification, specific
surface area, drugs structure and morphology
Copyright (C) Chemistry Dept., Moscow State University, 2002
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