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Anton Valentinovich Endutkin, Dmitry Olegovich Zharkov
Strategies
of N-glycosidic bond cleavage by DNA repair enzymes
Abstract
Abstract. DNA glycosylases are enzymes that hydrolyze the N-glycosidic
bond of damaged nucleotides, initiating the process of base excision DNA
repair. There are at least eight structural classes of these enzymes, differing
in both their substrate specificity and the mechanism of catalysis. The review
examines the mechanisms of human and bacterial DNA glycosylases that protect
the genome from the major types of DNA damage.
Key words: DNA damage, DNA repair, DNA glycosylases, catalytic mechanism
Copyright (C) Chemistry Dept., Moscow State University, 2002
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