Избранные главы химии
(курсы по выбору на английском языке)
Selected chapters of
chemistry: modern methods of investigation and analysis
проф. д.х.н. А.А. Карякин,
проф. д.х.н. Т.В. Магдесиева,
доц. к.х.н. М.Г. Чернышева,
проф. д.х.н. М.А. Проскурнин,
вед.н.сотр. д.х.н. М.К. Беклемишев,
проф. д.х.н. А.Т. Лебедев
Biosensors. Classification of biosensors and
their history. Biorecognition modes and samples of biomolecules involved.
Transducer types. Enzyme electrodes: three generation of biosensors.
Potentiometric biosensors and field effect transistors. Second generation
biosenosors: glucose oxidase and personal glucose tests.. Mediator based
systems. Commercialization. Third generation biosensors. Biosensors in
analysis of real objects.
electrochemical approaches to activation of organic molecules and
investigation of the reaction mechanism.
The lectures are aimed at the discussion of
the possibilities provided by application of
electrochemical techniques for solving a wide range of problems related to
reactivity of multifunctional organic, organometallic and coordination
compounds; investigation of their reaction mechanism and activation of
organic molecules using electrochemical electron transfer.
principles of radioactivity measuring.
Main principles of different types of
radioactivity determination will be discussed. Types of detectors (gas
ionization, solid state nuclear track, semiconductor, scintillation) will be
considered. Radioactivity counting statistics will be discussed.
scintillation analysis: principles and practice.
Basic principles of liquid scintillation
counter (Lsc) or analyzer (LSA) will be considered. Quench in liquid
scintillation counting and methods of quench correction in liquid
scintillation counting will be discussed. Practical applications of α/β
discrimination and analysis, and novel applications of liquid scintillation
counting will be reviewed.
method in studying biomolecules.
The lecture is devoted to the application of
hydrogen isotopes in biochemical and physical chemical studies. Methods of
synthesis of labeled compounds will be considered. The main principles of
tritium planigraphy and its application will be discussed.
Advances in Analytical Spectroscopy: 1. Vibrational Spectroscopy in Inorganic
and Organic Analysis
The lecture is dedicated to the blooming field
in modern analytical and physical chemistry, IR and Raman spectroscopy. A
brief introduction to the techniques will be given. The major techniques of
IR spectroscopy will be described. The applications of IR spectroscopy in
analysis of organic substances and rock and mineral materials will be
discussed. The lecture also covers the basics of far-IR (teraherz) and
near-IR spectroscopy applications and instruments.
advances in Analytical Spectroscopy: 2. Microspectroscopy, the unravelling
child of microscopy
The lecture is devoted with the recent
advances in spectroscopic techniques in microanalysis. The brief description
of microscopy and its development into the combination of microscopy and
spectroscopy, microspectroscopy will be provided. The basics and changes of
most demanded microspectroscopic techniques: transmission optical
spectroscopy, IR microscopic techniques, luminescent microspectroscopy and
photothermal spectroscopy with the examples and application will be
advances in Analytical Spectroscopy: 3. Microanalytical chemistry from
microfluidics to nanofluidics
The lecture is dedicated to the recent
advances in microanalytical chemistry, namely the branch of microanalysis
based on microfluidic application integrated microfluidic chips, lab-on-a
chip concept and the applications. Basic principles and advantages of
microfluidics in chemical analysis are described; a short history is given.
The main principles of microchip fabrication will be briefly provided, the
main detection techniques used in microfluidics are considered. Some
applications in synthetic chemistry and the basics of organ-on-a-chip concept
Advances in Analytical Spectroscopy: 4. State-of-the-art Applications of
The lecture is devoted to the de-facto
standard method for many trace elemental analysis problems, state-of-the-art
ICP-MS techniques. As not a basic-course lecture, a very short introduction
of the technique will be given, and the major topics covered are the
applications of various ICP-MS techniques in generic analytical problems, as
well as technological, clinical, and forensic problems. Special focus will be
paid to laser-ablation techniques, and novel instrumentation and technology
recognition in chemical analysis (non-biological aspects).
Types of interactions in molecular
recognition. Non-covalent binding: molecularly imprinted polymers, host-guest
complexes (crown ethers and cryptands for binding metal ions and organic
species; calixarenes, cyclodextrins), charge transfer complexes,
coordinatively unsaturated metal complexes. Covalent binding (boronic acids).
Binding and signaling ( “two-in-one”): fluorescent sensors based on synthetic
organic receptors, quantum dots, metal nanoparticles and nanoclusters.
Applications of molecular recognition: molecular imaging, chiral recognition,
molecular imprinting (in solid phase extraction and chromatorgaphy, quartz
crystal microbalance, electrochemical sensors).
aspects, field of applications and future prospects of mass spectrometry.
mass spectrometry is the most sensitive, informative, and reliable tool of
the qualitative and quantitative analysis of any type of chemical compounds
(from chemical elements to the most complex biopolymers). The method based on
the measurement of the accurate mass and concentration of molecules is
indispensable for the nucleus, chemical, oil industries, for the cosmic
studies, biology, medicine, nanotechnology, as well as for the defense
capability. The lectures will through light upon the basics of the method,
including sample introduction, ionization, separation and detection of the
ions. The theory will be accompanied by the examples demonstrating the unique
possibilities of mass spectrometry to resolve chemical, biological, medical,
ecological tasks, its application in doping-control, forensic sciences,