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Maxim F. Subach, Maria G. Khrenova, Maria I. Zvereva
Modern methods of aptamer chemical modification and
principles of aptamer library selection
Abstract
Abstract. Aptamers are promising molecules for a
wide range of applications in biomedicine and various diagnostic systems due to
their unique properties as selective ligands, specifically obtained for a
selected target using methods of artificial evolution and combinatorial
chemistry. We discuss strategies of obtaining aptamers in vitro and
using their chemical modifications, as well as approaches to design initial
compound libraries based on in silico pre-structuring. Limitations are
formulated, and a direction for the development of the field in obtaining new
aptamers is proposed.
Key words: artificial evolution, aptamers,
modification, nucleic acids, combinatorial chemistry
Copyright (C) Chemistry Dept., Moscow State University, 2002
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