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Svetlana M. Filatova, Ulyana A. Budanova, Yuri L. Sebyakin
Mono-/Bivalent Cationic Lipoamino Acids and Atypical
Lipopeptides Based on Symmetric Diethanolamine Esters
Abstract
Abstract. This work
describes the synthesis of cationic amphiphiles based on aliphatic and aromatic
amino acids and diethanolamine derivatives. The calculation of the
hydrophilic-lipophilic balance of a number of structures made it possible to
identify structures with potential antimicrobial activity against gram-positive
and gram-negative bacterial strains. Schemes for the synthesis of mono/bivalent
cationic lipoamino acids and lipopeptides have been developed. Two series of
amphiphiles were obtained in preparative quantities for subsequent
microbiological studies and determination of the minimum inhibitory
concentration.
Key words: lipopeptides,
cationic amphiphiles, diethanolamine, HLB, antibacterial activity, L-lysine,
L-alanine, L-tyrosine, L-phenylalanine
Copyright (C) Chemistry Dept., Moscow State University, 2002
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