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Khalili A. S., Domogatsky S. P., Ruuge E. K.

A mathematical approach to enzyme treatment of burn wounds: proteolytic activity is restricted by specific inhibitor counterflow.

Abstract

A mathematical model of proteolytic enzyme applied to the surface of burn wound penetration into the depth of necrotic tissue has been considered. The model approximation describes three factors by a series of mathematical equations: inward-directed enzyme diffusion, counter-flow filtration of interstitial fluid (exudates), and irreversible inactivation of the enzyme by specific inhibitors present in exudates. Character time hierarchy is defined for these processes.
Dependence of the main characteristics of the enzyme therapy effect on the applied enzyme concentration has been determined. It has been shown, that the depth of enzyme propagation into necrotic tissue is restricted by counterflow of specific inhibitor; therefore internal stratum of necrotic tissue layer containing unbound inhibitor protects underlying intact tissues and granulations from proteolytic action of applied enzyme.
Moscow University Chemistry Bulletin.
2003, Vol. 44, No. 1, P. 31
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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